DISORDER
MECHANISM · CAUSE
FEATURES
CLUE · TREATMENT
Presbycusis
most common hearing loss
Age-related loss of cochlear hair cells at the base
Bilateral symmetric high-frequency sensorineural loss; trouble hearing speech in noise
Hearing aids
Noise-induced hearing loss
Outer hair cell damage from chronic or blast noise
Sensorineural loss with a notch near 4 kHz; tinnitus
Prevent with ear protection
Hair cell injury
Aminoglycosides, cisplatin, loop diuretics (furosemide, ethacrynic acid), vancomycin, aspirin (reversible tinnitus)
Aminoglycoside + loop diuretic = additive
Congenital & genetic hearing loss
Infection or inherited defects
Congenital CMV (most common nongenetic), rubella, syphilis, toxoplasmosis; Alport, Usher, Pendred, Waardenburg
Newborn hearing screen
Sudden sensorineural hearing loss
Often idiopathic (viral, vascular)
Rapid unilateral loss over < 72 h, tinnitus, fullness
Urgent steroids · MRI for schwannoma
Schwann cells of CN VIII at the cerebellopontine angle; bilateral = NF2
Unilateral sensorineural loss, tinnitus, imbalance; later CN VII and V signs
Asymmetric hearing loss → MRI
Otoconia (calcium carbonate) loose in a semicircular canal (posterior)
Brief vertigo (< 1 min) on head position change (rolling in bed); no hearing loss
Dix-Hallpike ⁺ · Epley maneuver
Endolymphatic hydrops (↑ endolymph)
Episodes lasting hours: vertigo + fluctuating low-frequency sensorineural loss + tinnitus + aural fullness
Salt restriction, diuretics
Vestibular neuritis · labyrinthitis
Viral inflammation of the vestibular nerve · of the labyrinth
Days of continuous vertigo, nausea, nystagmus; neuritis: hearing normal · labyrinthitis: hearing loss
Supportive, short vestibular suppressants
Brainstem or cerebellar stroke, MS, tumor
Vertical or direction-changing nystagmus, ataxia, other neuro signs; normal head-impulse test
Emergency MRI
Olfactory: viral URI (incl. COVID-19), head trauma (cribriform plate), Kallmann, early Parkinson/Alzheimer · taste: CN VII (anterior ⅔), CN IX, zinc deficiency
Anosmia, dysgeusia
Anosmia + hypogonadism → Kallmann